6/17/2023 0 Comments Grapefruit and statinsUnlike oils, edibles, and vaping solutions, topicals don’t typically enter the bloodstream - as long as they’re not a transdermal solution intended to do so. Keep in mind that topical CBD, like lotions, creams, and salves, may also be an option. For some situations, your doctor may want to monitor blood plasma levels of certain medications you take.ĭon’t stop any of your medications to try CBD, unless your doctor says it’s safe to do so. They may be able to help determine a CBD product, dosage, and schedule that’s safe with your medications. If you want to try CBD as an add-on therapy to ease symptoms of a certain condition, talk to your doctor about it first. Trying CBD safely while taking medications If your body is metabolizing a medication too fast because another substance is inducing the enzymes, you may not have enough of the medication in your system at one time to treat a health issue. Some substances also speed up the work of the CYP450 enzyme family. An increased level of a medication in your system could exaggerate its effects, including unwanted or harmful side effects. If your body is metabolizing a medication too slowly, you may have more medication in your system at one time than intended - even if you’ve stuck to your normal dose. If you then take CBD while on these medications, your body can’t work to process the CBD as effectively. But if CBD is inhibiting CYP3A4, it can’t work as effectively to break down the medications in your system. The CYP3A4 enzyme is in charge of metabolizing about 60 percent of clinically prescribed medications. But during this process, CBD also interferes with CYP3A4. Specifically, CYP3A4, an important enzyme within the CYP450 family, does the task. The CYP450 family of enzymes is responsible for metabolizing several cannabinoids, including CBD, research shows. Why does CYP450 matter when it comes to CBD and medications? That change in metabolism rate can alter how your body processes the medications or supplements you take - hence a drug interaction. Drug metabolism happens throughout the body, such as in the gut, but the liver does a big part of the job, too.Ī family of enzymes called cytochrome P450 (CYP450) does the important work of converting foreign substances so they can easily be eliminated from the body.īut some medications or substances affect CYP450, either by slowing or speeding up drug metabolism. When you take a medication or other substance, your body has to metabolize it, or break it down.
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